Treatment and Management

Understand The 3 Goals Of Treatment

The goals of treating hypercortisolism are to1:

Target the
underlying cause

Improve signs and
symptoms

Enhance quality
of life

In General, Surgery Is The Recommended First-line Treatment For Eligible Patients2,3

  • A systematic review of patients with hypercortisolism demonstrated 51.5% improvement in type 2 diabetes (T2D) and 60.5% improvement in hypertension with adrenalectomy when compared with standard-of-care T2D and hypertension treatments4

When To Consider Medical Therapy

Medical therapy may be used to improve the comorbidities associated with hypercortisolism for patients who are not candidates for surgery or have failed surgery.2

Several medical therapies can help manage the impact of elevated cortisol by2:

Inhibiting key enzymes needed to produce cortisol2

Targeting key cells in pituitary adenomas to inhibit adrenocorticotropic hormone secretion2

Modulating cortisol activity by competing with cortisol at the glucocorticoid receptor2

  • Medical therapy for hypercortisolism is not intended to replace medications that manage comorbidities2

  • Dose adjustments to medications and continued monitoring may be required2

  • To optimize patient outcomes, it is important to select the appropriate treatment that can manage hypercortisolism and its associated comorbidities2

Discover a treatment for patients with T2D and hypercortisolism

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Discuss the recent prevalence data with a Corcept representative

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Learn more about hypercortisolism

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References

1. Nieman LK, Biller BM, Findling JW, et al. J Clin Endocrinol Metab. 2015;100(8):2807-2831. doi:10.1210/jc.2015-1818 2. Fleseriu M, Auchus R, Bancos I, et al. Lancet Diabetes Endocrinol. 2021;9(12):847-875. doi:10.1016/S2213-8587(21)00235-7 3. Zeiger MA, Thompson GB, Duh QY, et al. Endocr Prac. 2009;15(suppl 1):1-20. doi:10.4158/EP.15.S1.1 4. Bancos I, Alahdab F, Crowley RK, et al. Eur J Endocrinol. 2016;175(6):R283-R295. doi:10.1530/EJE-16-0465 5. DeFronzo RA, Auchus RJ, Bancos I, et al. BMJ Open. 2024;14(7):e081121. doi:10.1136/bmjopen-2023-081121